含丹参腹膜透析液对动脉硬化的影响

目的:观察丹参对维持性腹膜透析(CAPD)患者动脉硬化的影响。方法:38例CAPD患者随机分为对照组(常规透析)和治疗组(常规透析加丹参),分别测定各组基础以及透析6月后血常规、肝肾功能、血脂血压、颈动脉内膜中层厚度(IMT)等。结果:①两组患者IMT随着治疗时间的延长均呈上升趋势,两组治疗后比较,差异有统计学意义(P<0.05)。②两组患者治疗后比较,血压、血脂均已达标,差异无统计学意义(P>0.05);血尿素氮(BUN)、血肌酐(Scr)、血清白蛋白(ALB)、血红蛋白(Hb)水平稳定,差异无统计学意义(P>0.05)。结论:CAPD患者随着治疗时间的延长普遍存在动脉硬化,丹参可延缓患者动脉硬化的进程。

Impacts of Danshen on Atherosclerosis in Peritoneal Dialysis Patients

Objective ： To investigate the impacts of Danshen on atherosclerosis in continuous ambulatory peritoneal di- alysis（CAPD） patients. Methods： 38 CAPD patients were divided into control group （no Danshen addition）and experi- mental group （ with Danshen in peritoneal fluid）, Hemoglobin （Hb） , Albumin （ ALB ）, Blood urea nitrogen （ BUN）, serum creatinine（Scr） , blood fat,.blood .pressure and intima -media thickness （IMT）were observed before and 6 months after peritoneal dialysis. Result： IMT upgraded with the dialysis time in all CAPD patients, and there were significant differ- ences six months later between the two groups（ P 〈0.05）. The blood levels of BUN,Scr,ALB and Hb were stable（ P 〉 0.05）. Blood fat, blood Pressu~-e reached aims, and there were no significant differences between the two groups （ P 〉 O. 05 ）. Conclusion： Atherosclerosis is universal with the dialysis time increasing in CAPD patients. Danshen can delay the progression of atherosclerosis.