| 不同比例川芎当归共煎液指纹图谱考察 |
| |
| 引用本文： | 宋金春,代军,以盛,黄岭. 不同比例川芎当归共煎液指纹图谱考察[J]. 中国药房, 2007, 18(9): 677-679 |
| |
| 作者姓名： | 宋金春 代军 以盛 黄岭 |
| |
| 作者单位： | 1. 武汉大学人民医院药学部,武汉市,430060
2. 武汉大学药学院,武汉市,430072 |
| |
| 摘 要： | 目的:考察不同比例川芎、当归共煎液指纹峰的变化情况。方法:采用高效液相色谱法,以ZorbaxSB-C18(250mm×4.6mm,5μm)为色谱柱,以甲醇-0.5%醋酸水溶液为流动相进行梯度洗脱,检测波长为313nm。结果:不同比例川芎、当归共煎液中未发现新峰生成;川芎、当归指纹峰具有加合性,但并非简单加合,某些成分的煎出量受配比的影响,川芎∶当归=7∶3时阿魏酸煎出量最大。结论:本研究可为抗心血管药物的开发提供思路。
|
| 关 键 词： | 指纹图谱 高效液相色谱法 阿魏酸 当归 川芎 共煎液 |
| 文章编号： | 1001-0408(2007)09-0677-03 |
| 收稿时间： | 2006-06-07 |
| 修稿时间： | 2006-08-14 |
Study on the Water Extracts'''' Fingerprint of Ligusticum Chuanxiong Hort.Concomitant with Angelica Sinensis in Different Ratio |
| |
| SONG Jinchun,DAI Jun,YI Sheng,HUANG Ling. Study on the Water Extracts'''' Fingerprint of Ligusticum Chuanxiong Hort.Concomitant with Angelica Sinensis in Different Ratio[J]. China Pharmacy, 2007, 18(9): 677-679 |
| |
| Authors: | SONG Jinchun DAI Jun YI Sheng HUANG Ling |
| |
| Abstract: | OBJECTIVE:To study the fingerprint of Ligusticum chuanxiong Hort.concomitant with Angelica sinensis in different ratio boiled in water.METHODS:The gradient elution mode was applied in chromatographic separation.The stationary phase was Zorbax SB-C18(250mm× 4.6mm,5μ m).The mobile phase consisted of methanol∶ water(containing 0.5% acetic acid).The UV detection was performed at 313 nm.RESULTS:No new substances were found in the water extracts of Li-gusticum chuanxiong Hort.concomitant with Angelica sinensis.Some ingredients released better when the two drugs boiled together with water.Ligusticum chuanxiong Hort.concomitant with Angelica sinensis at the ratio of 7∶ 3 had a bigger concentration of Ferrulic acid in water extract.CONCLUSION:The research provides the new way of R& D of cardiovascular drugs. |
| |
| Keywords: | Fingerprint HPLC Ferrulic acid Angelica sinensis Ligusticum chuanxiong Hort. Water extract |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
