The interaction of erythromycin with theophylline |
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| Authors: | O. Paulsen P. Höglund L. -G. Nilsson H. -I. Bengtsson |
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| Affiliation: | (1) Department of Pharmacology, University of Frankfurt, Frankfurt/Main, Federal Republic of Germany;(2) Department of Medicine, University of Freiburg, Freiburg, Federal Republic of Germany;(3) School of Pharmacy, University of California, 94143-0446 San Francisco, CA, USA |
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| Abstract: | Summary The pharmacokinetics of the antikaliuretic amiloride has been studied in healthy controls and in patients with chronic renal failure or hepatitis. It was 40% bound to protein.In healthy volunteers 49% of an oral dose was recovered unchanged in the urine. The renal clearance of amiloride was about 3 times the creatinine clearance, which means that it was predominantly excreted via tubular secretion.Renal impairment reduced the clearance of amiloride, causing a prolongation of the t1/2 and drug accumulation in plasma. In hepatitis the t1/2 of amiloride was prolonged and the AUC increased. Urinary recovery (Ae) of amiloride was greater in hepatitis patients than in controls. |
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| Keywords: | amiloride pharmacokinetics renal failure liver disease urinary excretion |
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