| 复健片对大脑中动脉闭塞模型大鼠脑组织P-4502C11mRNA表达的影响 |
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| 引用本文： | 刘伟. 复健片对大脑中动脉闭塞模型大鼠脑组织P-4502C11mRNA表达的影响[J]. 山东中医药大学学报, 2010, 0(2) |
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| 作者姓名： | 刘伟 |
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| 作者单位： | 山东中医药大学; |
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| 基金项目： | 国家自然科学基金资助项目(编号:30801470) |
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| 摘 要： | 目的:探讨复健片对大脑中动脉闭塞(MCAO)模型大鼠脑组织P-4502C11mRNA表达的影响。方法:将72只雄性Wistar大鼠随机分为假手术组、模型组和药物组,每组24只,采用电凝大脑中动脉手术造模。自术后1周末始,药物组给予复健片水溶液灌胃,其余两组给予等量生理盐水。在每个观察时点(1周、2周、3周末),各组随机抽取8只大鼠,采用激光多普勒血流仪测定梗死侧额叶局部脑血流量(rCBF),用RT-PCR技术测定梗死额叶周围皮质P-4502C11mRNA的表达。结果:造模结束1周后,与假手术组比较,模型组与药物组梗死侧额叶皮质rCBF、P-4502C11mRNA表达量均显著降低(P<0.01);而治疗1周、2周后,药物组与同期模型组比较,梗死侧额叶皮质的rCBF均有所增加(均为P<0.05),同时,P-4502C11mRNA表达量亦显著增强(分别为P<0.05,P<0.01)。结论:复健片可上调MCAO大鼠受损侧脑组织中原本因缺血而下调的P-4502C11mRNA表达,增强星形胶质细胞释放环氧-二十碳三烯酸(EETs)的能力,这可能是本药改善受损脑组织血流灌注的重要机制之一。
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| 关 键 词： | 复健片 P-4502C11mRNA 大脑中动脉闭塞 实验研究 |
Effect of Fujian tablets on expression of P-4502C11mRNA in middle cerebral artery occlusion rats |
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| LIU Wei. Effect of Fujian tablets on expression of P-4502C11mRNA in middle cerebral artery occlusion rats[J]. Journal of Shandong University of Traditional Chinese Medicine, 2010, 0(2) |
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| Authors: | LIU Wei |
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| Affiliation: | LIU Wei(Sh,ong University of Traditional Chinese Medicine,Jinan 250355,China) |
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| Abstract: | Objective:To investigate effect of Fujian tablets on expression of P-4502C11mRNA in middle cerebral artery occlusion(MCAO) rats.Methods:72 male Wistar rats were randomly divided into three groups(n=24 in each group):sham operation,model and drug groups.Middle cerebral artery was occluded by electrocoagulation to make MCAO model.From the end of 1 week after operation,the solution of Fujian tablets was given to drug group by gavage method and equal dose of normal salines were given to other two groups.At thre... |
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| Keywords: | Fujian tablets P-4502C11mRNA middle cerebral artery occlusion experimental study |
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