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Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses
Authors:Guo Yuhong  Di Tingting  Zhao Jingxia  Xu Xiaolong  Li Ping  Huang Lijuan  Liu Qingquan
Institution:1. Intensive Care Unit, Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing 100010, China;2. Beijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing 100010, China
Abstract:

OBJECTIVE

To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections.

METHODS

We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decoction. Rats were orally administered with Fuxin decoction from 10 to 40 mg/kg. Organization structure changes were assessed by histology, circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent assay.

RESULTS

Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection rats. Cardiac involvement was alleviated by Fuxin decoction, as well as changes of congestion systemic circulation in this rat models. Furthermore, Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced rats.

CONCLUSION

Fuxin decoction might be an interesting candidate for congestive heart failure.
Keywords:Fuxin decoction  Doxorubicin  Congestive heart failure  Oxidizing suppression  Immune regulation
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