| 藤黄酸对人肝癌细胞株SMMC-7721的基因表达谱的影响(英文) |
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| 引用本文： | 卢娜, 顾红燕, 尤启冬, 杨勇, 郭青龙. 藤黄酸对人肝癌细胞株SMMC-7721的基因表达谱的影响(英文)[J]. 中国药科大学学报, 2007, 38(5): 424-428. |
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| 作者姓名： | 卢娜 顾红燕 尤启冬 杨勇 郭青龙 |
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| 作者单位： | 1.中国药科大学江苏省肿瘤发生与干预重点实验室 |
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| 基金项目： | 教育部科技司资助项目;国家自然科学基金;江苏省自然科学基金 |
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| 摘 要： | 目的:研究藤黄酸对人肝癌细胞株SMMC-7721基因表达图谱的影响。方法:使用cDNA基因芯片及RT-PCR的方法检测基因表达情况。结果:与对照组相比,给于藤黄酸24h后,有31个基因改变,给予藤黄酸48h后有56个基因改变。结论:藤黄酸的抗肿瘤作用机制可能与凋亡、转移以及影响细胞周期有关。
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| 关 键 词： | 藤黄酸 基因芯片 原发性肝癌 |
| 文章编号： | 1000-5048(2007)05-0424-05 |
| 修稿时间： | 2007-01-10 |
Gene expression spectra in human hepatoma SMMC-7721 cells treated with gambogic acid |
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| LU Na,GU Hong-yan,YOU Qi-dong,YANG Yong,GUO Qing-long. Gene expression spectra in human hepatoma SMMC-7721 cells treated with gambogic acid[J]. Journal of China Pharmaceutical University, 2007, 38(5): 424-428 |
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| Authors: | LU Na GU Hong-yan YOU Qi-dong YANG Yong GUO Qing-long |
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| Affiliation: | Jiangsu Key laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Aim: To investigate gene expression spectra in human hepatoma cell line SMMC-7721 treated with gambogic acid (GA).Methods:Human cDNA microarray and RT-PCR technology were used to detect the changes in gene expression. Results: 31 genes in groups exposed to gambogic acid for 24 h and 56 genes for 48 h group were expessed differentially in comparison to the control group. Conclusior:The antitumor mechanism of GA might focus on apoptosis,metastasis as well as interfering with the cell cycle. |
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| Keywords: | gambogic acid microarray primary hepatocellular carcinoma |
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