Monoamine accumulating neuron system in the rat retina with special reference to noradrenaline accumulating neurons |
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| Authors: | Masakatsu Fukuda Ichiro Ishimoto Yasuaki Kuwayama Yoshiki Shimizu Sadao Shiosaka Hiroshi Takagi Masaya Tohyama |
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| Affiliation: | 1. Department of Ophthalmology, Institute of Higher Nervous Activity, Osaka University Medical School, 1-1-50 Fukushima, Fukushimaku, Osaka, Japan;2. Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School, 1-1-50 Fukushima, Fukushimaku, Osaka, Japan |
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| Abstract: | The uptake capacity of the retinal neurons for exogenously administered monoamines was examined in the rat. The present study confirmed the presence of 5,6-dihydroxytryptamine (5,6DHT) accumulating retinal neurons in the rat retina and further disclosed that some retinal cells could accumulate exogenously injected noradrenaline (NA). These NA-labeled cells occupied approximately similar positions in the inner nuclear layer to the 5,6DHT-labeled ones, but the two groups of cells were not identical because simultaneous injections of 5,6DHT and NA demonstrated two types of cells, one having yellow and the other showing green fluorescence, respectively. It should be stressed that these two groups of cells are easily distinguishable from well-known dopamine-containing neurons by their sizes and cell locations. The present study further suggested that the NA-accumulating retinal cells might not contain the NA synthesizing enzyme. |
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| Keywords: | noradrenaline uptake capacity histofluorescence rat retina |
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