160例米非司酮配伍米索前列醇不同给药方式在终止孕早期妊娠临床应用

目的:探讨米非司酮配伍米索前列醇不同给药方式在孕6～13周早孕引产中的应用效果。方法:回顾分析2006年1月～2009年10月要求终止妊娠患者160例。分析米非司酮配伍米索前列醇早孕引产的临床疗法及安全性,米非司酮总剂量为150mg,根据不同服药方法分为两日服法和3日服法;根据米索前列醇不同给药方式分为口服给药和阴道给药;将160例实验对象分为4组:A组米非司酮3日服法,第3日晨顿服米索前列醇500mg;B组米非司酮服法同A组,第3天晨阴道置入米索列醇500mg;C组米非司酮两日服法,第3天空腹顿服米索前列醇500mg;D组米非司酮服法同C组,第3天晨阴道置入米索前列醇500mg。结果:米非司酮配伍米索前列醇引产4组成功率均令人满意。相同剂量的药物,相同的给药途径引产效果差异无统计学意义(P>0.05),而不同的给药途径引产效果差异有统计学意义(P<0.05)。结论:非米司酮两日服法,即75mg每天1次顿服共2天,配伍米索前列醇500mg阴道给药的早期引产方法更为简便、安全、有效、痛苦小,值得临床推广应用。

Clinical application of mifepristone and misoprostol of different administration methods in termination of pregnancy in 160 pregnant women in the first trimester pregnancy

Objective:To explore the effect of mifepristone and misoprostol of different administration methods on termination of pregnancy in pregnant women of 6~13 gestational weeks.Methods:160 pregnant women demanding termination of pregnancy from January 2006 to October 2009 were analyzed retrospectively,clinical therapy and safety of abortion induced by mifepristone and misoprostol in the first trimester pregnancy were analyzed,the total amount of mifepristone was 150 mg,then was divided into two-day dosage method and three-day dosage method according to different administration methods;misoprostol was divided into oral administration and viginal administration according to different administration methods;160 women were divided into four groups:group A:mifepristone,three-day dosage method,draught of misoprostol 500 mg on the morning of the third day;group B:mifepristone,three-day dosage method,500 mg misoprostol of viginal administration on the morning of the third day;group C:mifepristone,two-day dosage method,draught of misoprostol 500 mg on the morning of the third day;group D:mifepristone,two-day dosage method,500 mg misoprostol of viginal administration on the morning of the third day.Results:The success rates of induced labor in the four groups were satisfied,there was no difference in effect of induced labor among same dose and same administration method(P>0.05),but there was significant difference among different administration methods(P<0.05).Conclusion:Mifepristone(two-day dosage method,75 mg per time,once a day for two days)and misoprostol(500 mg,viginal administration)are safe,effective,less pain in induced labor of pregnant women in the first trimester pregnancy.