B超筛查胎儿缺陷与染色体异常相关性的初步探讨

目的:探讨B超筛查胎儿缺陷与染色体异常的相关性。方法:对照组选取孕12～24周正常胎儿520名经B超产科软件测量八项生物学指标,测值进行统计学分析。实验组选取妊娠12～24周孕妇4736例经B超产科软件测量胎儿八项生物指标,异常者经介入超声作羊水细胞染色体核型分析。结果:对照组得出孕12～24周正常胎儿各项指标的正常参考值范围;实验组筛查结构畸形胎儿64例(1.35%)中,59例(92.19%)染色体核型正常,5例(7.81%)染色体核型异常,发现颈项水囊瘤、全前脑畸形合并上肢内翻及心脏畸形3种类型畸形,超声与染色体检查结果符合率较高。结论:超声筛选胎儿染色体异常切实可行。

The correlation analysis on chromosome abnormality and the fetal defect screened by B ultrasonic

Objective:To investigate the relationship between chromosome abnormality and the fetal defect screened by B ultrasonic Methods:12～24 weeks fetus were divided into control group (n=520) and study group(n=4736),eight-biological indicators of the two groups were measured by an obstetric software and were analyzed..Results:The normal reference range of the indicators were got from the control group.In the experimental group,64 cases were malformation (1.35%),59 of the 64 (92.19%) were with normal chromosome karyotype,5 of the 64 ( 7.81%) were with abnormality chromosome karyotype.The coincidence rate of ultrasonic examination and chromosome results is higher Conclusion:Ultrasound screening of fetal chromosome abnormality is practicable.