欣普贝生用于促宫颈成熟的临床探讨

目的:探讨控释前列腺素E2栓剂-欣普贝生用于足月促宫颈成熟的有效性及安全性。方法:对116例孕周超过40周、Bishop宫颈评分<6分、无妊娠合并症、单胎、头位并要求阴道试产的初孕妇,以阴道放置欣普贝生促宫颈成熟作为研究组,另选78例同样条件的初孕妇用催产素促宫颈成熟作为对照组。比较两组孕妇的Bishop评分变化、临产情况及分娩的发生时间、剖宫产率、对胎儿及新生儿的影响。结果:研究组孕妇给药后,24 h后68例直接进入产程,其余40例Bishop评分提高≥2分,而对照组仅2例进入产程,28例Bishop评分提高≥2分,两组比较,差异有统计学意义(P<0.01)。研究组从给药到临产的时间为(13±4.5)h,对照组为(32±10.5)h,两组比较,差异有统计学意义(P<0.01)。研究组的剖宫产率为32.1%,而对照组则为48.1%。结论:欣普贝生可安全、有效地用于足月促宫颈成熟。

Clinical application of prostaglandin E2 suppository in promoting cervical ripening

Objective:To explore the effectiveness and safety of prostaglandin E2 suppository in promoting cervical ripening.Methods:116 primiparous women(gestational weeks >40 weeks,cervical Bishop score<6,without pregnant complications,single pregnancy,head position) undergoing vaginal administration of prostaglandin E2 suppository in order to promote cervical ripening were selected as study group,78 primiparous women with the same conditions receiving oxytocin were selected as control group,the effects of changes of cervical Bishop score,in labor conditions and time interval from administration to delivery,cesarean section rates on fetuses and neonates in the two groups were compared.Results:After administration in study group,68 pregnant women were in labor after 24 hours,the cervical Bishop score of 40 pregnant women increased by more than 2;in control group,2 pregnant women were in labor,the cervical Bishop score of 28 pregnant women increased by more than 2,there was significant difference(P< 0.01);the time intervals from administration to delivery were(13±4.5) hours in study group and(32±10.5) hours in control group,there was significant difference(P< 0.01);the rates of cesarean section were 32.1% in study group and 48.1% in control group.Conclusion:Prostaglandin E2 suppository is safe and effective in promoting cervical ripening in term pregnancy.