| A preliminary study on the loss of heterozygosity at 17p13 in gastric and colorectal cancers |
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| 引用本文： | WU Guo Jun 1,SHAN Xiang Nian 2,LI Ming Fa 2,SHI Shao Lin 1,ZHENG Qi Ping 1,YU Long 1 and ZHAO Shou Yuan 1. A preliminary study on the loss of heterozygosity at 17p13 in gastric and colorectal cancers[J]. World journal of gastroenterology : WJG, 1997, 0(3) |
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| 作者姓名： | WU Guo Jun 1 SHAN Xiang Nian 2 LI Ming Fa 2 SHI Shao Lin 1 ZHENG Qi Ping 1 YU Long 1 and ZHAO Shou Yuan 1 |
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| 作者单位： | WU Guo Jun 1，SHAN Xiang Nian 2，LI Ming Fa 2，SHI Shao Lin 1，ZHENG Qi Ping 1，YU Long 1 and ZHAO Shou Yuan 1 |
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| 摘 要： | Ａｐｒｅｌｉｍｉｎａｒｙｓｔｕｄｙｏｎｔｈｅｌｏｓｓｏｆｈｅｔｅｒｏｚｙｇｏｓｉｔｙａｔ１７ｐ１３ｉｎｇａｓｔｒｉｃａｎｄｃｏｌｏｒｅｃｔａｌｃａｎｃｅｒｓＷＵＧｕｏＪｕｎ１，ＳＨＡＮＸｉａｎｇＮｉａｎ２，ＬＩＭｉｎｇＦａ２，ＳＨＩＳｈａｏＬ...
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A preliminary study on the loss of heterozygosity at 17p13 in gastric and colorectal cancers |
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| WU Guo Jun ,SHAN Xiang Nian ,LI Ming Fa ,SHI Shao Lin ,ZHENG Qi Ping ,YU Long and ZHAO Shou Yuan. A preliminary study on the loss of heterozygosity at 17p13 in gastric and colorectal cancers[J]. World journal of gastroenterology : WJG, 1997, 0(3) |
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| Authors: | WU Guo Jun SHAN Xiang Nian LI Ming Fa SHI Shao Lin ZHENG Qi Ping YU Long ZHAO Shou Yuan |
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| Affiliation: | WU Guo Jun 1,SHAN Xiang Nian 2,LI Ming Fa 2,SHI Shao Lin 1,ZHENG Qi Ping 1,YU Long 1 and ZHAO Shou Yuan 1 |
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| Abstract: | AIM To evaluate the role of p53 gene involved in the development and progression of colorectal cancer and gastric carcinoma by analyzing the loss of heterozygosity (LOH) at 17p13 1 and 17p13 3. METHODS LOH at p53 gene and 17p13 3 were examined in 22 cases of gastric carcinoma and 14 cases of colorectal cancer with Southern blot analysis. RESULTS In 22 cases of gastrocarcinoma, 12(54%) were of heterzygosity and LOH was detected in 6(50%) of 12 informative cases. In the 14 cases of colorectal cancer, 10(71%) were of heterzygosity and LOH was detected in 6(60%) of 10 informative cases. CONCLUSION LOH of p53 gene is a frequent event in the multiple step progression of carcinogenesis. The high frequency of LOH at 17p13 3 suggests that there may be another tumor suppresser gene. |
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| Keywords: | stomach neoplasms colorectal neoplasms p53 gene heterozygosity loss genes suppressor tumor |
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