肝癌组织中β-葡萄糖醛酸酶mRNA与临床病理因素的关系

目的 探讨肝癌组织中β-葡萄糖醛酸酶(β-glucuronidase,β-G)mRNA的表达与临床病理因素的关系.方法 采用RT-PCR法检测25例肝癌组织及10例正常肝组织中β-G mRNA的表达,并分析肝癌组织中β-G mRNA与临床病理因素的关系.结果 患者的年龄、肿瘤大小、AFP水平不影响肝癌组织中β-G mRNA的表达.β-G mRNA的表达在有门静脉癌栓以及淋巴结转移者中明显高于无门静脉癌栓以及淋巴结转移者(t=7.857,9.341,P＜0.05).结论 β-G mRNA的表达与肝癌患者有无门静脉癌栓及淋巴结转移等临床病理因素密切相关,β-G可能在肝癌细胞的侵袭和转移过程中起一定的作用.

Relationship between the expression of β-glucuronidase mRNA in hepatocellular carcinoma tissue and the clinicopathologic factors

Objective To investigate the relationship between the expression of β-glucuronidase mRNA in hepatocellular carcinoma(HCC)tissue and the clinicopathologic factors.Methods The expressions of β-glucuronidase mRNA in 25 samples of HCC tissue and 10 samples of normal hepatic tissue were detected by RT-PCR,and the relationship between β-glucurenidase mRNA in HCC tissue and clinicopathologic factors was analyzed.Results The expression of β-glucuronidase mRNA in HCC tissue was not influenced by the age of patient,tumor size and alpha-fetoprotein level.The expression of β-glueuronidase mRNA in patients with portal vein tumor thrombus or lymph node metastasis Was significantly higher than those without(t=7.857,9.341,P＜0.05).Conclusions The expression of β-glucuronidase mRNA is closely related to the existence of portal vein tumor thrombus and lymph node metastasis.β-glucuronidase may play a role in the invasion and metastasis of HCC.