硬膜外自控镇痛对子痫前期患者剖宫产术后转归的影响

目的:探讨硬膜外自控镇痛对子痫前期患者剖宫产术后转归的影响。方法:子痫前期剖宫产术病人59例,分为两组。Ⅰ组为镇痛组共30例,术毕以0.125%左旋布比卡因100ml,混合吗啡20μg/ml行自控硬膜外镇痛,PCEA设置为单次剂量2ml,定时20min,总量100ml,背景输注2ml/h。Ⅱ组为对照组共29例,未作术后镇痛。观察两组产妇术后24h、48h的VAS评分及呼吸抑制、恶心、呕吐、皮肤瘙痒、嗜睡、头晕等不良反应的发生情况;记录术后1～6天清晨血压、心率、呼吸、SpO2及尿蛋白情况。结果两组病人术后24h、48hVAS评分有显著差异(P<0.01)。镇痛组术后收缩压、舒张压和尿蛋白含量均显著下降(P<0.01),且未发生产后子痫。结论:硬膜外自控镇痛有利于子痫前期患者剖宫产术后的恢复。

The effect of PCEA on patient with pre -eclampsia underwent caesarian section.

Objective:To investigate the effect of PCEA on patient with pre-eclampsia underwent caesarian section.Methods:59 patients with pre-eclampsia underwent caesarian section were randomly divided into two groups.All patients in group Ⅰ were administrated PCEA with 0.125% levobupivacaine plus 20 μg/ml morphine by analgesia pump setting as infusion rate 2 ml/h,bolus 2 ml,interval time 20 min and capacity 100 ml.Group Ⅱ received no PCEA as control group.The VAS at 24 h and 48 h in the both two group were recorded together with the side effect such as breath depression,nausea,vomiting,itching and faint.Blood pressure and content of urine albumen were observed on 1,2,3,4,5,6 days after the operation.Results:The VAS were significantly different between the two groups(P<0.01).Blood pressure and content of urine albumen were observed descended significantly.No eclampsia was recorded in the Group I,while 3 in the Group Ⅱ.Conclusion:PCEA on patient with pre-eclampsia underwent caesarian section is effective and safe.