| 基质金属蛋白酶-1在人涎腺腺样囊性癌细胞中的表达 |
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| 引用本文： | 朱秀丽,郭青玉,温德升,王静,吴军正. 基质金属蛋白酶-1在人涎腺腺样囊性癌细胞中的表达[J]. 实用口腔医学杂志, 2012, 28(3): 324-327 |
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| 作者姓名： | 朱秀丽 郭青玉 温德升 王静 吴军正 |
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| 作者单位： | 1. 武警总医院口腔科, 北京,100039
2. 第四军医大学口腔医学院口腔生物教研室 |
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| 基金项目： | 国家自然科学基金资助项目(编号:30371551) |
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| 摘 要： | 目的:测定基质金属蛋白酶-1(MMP-1)在人涎腺腺样囊性癌不同转移力细胞系中的表达。方法:以人涎腺腺样囊性癌ACC-2细胞系及其高转移株ACC-M作为研究肿瘤转移分子机制的模型,采用免疫组化法和蛋白印迹(Western blot)法检测MMP-1的蛋白表达水平。结果:MMP-1在ACC-M细胞中的表达水平高于ACC-2细胞。结论:MMP-1在人涎腺腺样囊性癌的侵袭转移过程中可能发挥作用。
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| 关 键 词： | MMP-1 人涎腺腺样囊性癌细胞系 肿瘤转移 |
Expression of MMP-1 in human salivary gland adenoid cystic carcinoma cells |
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| ZHU Xiuli , GUO Qingyu , WEN Desheng , WANG Jing , WU Junzheng. Expression of MMP-1 in human salivary gland adenoid cystic carcinoma cells[J]. Journal of Practical Stomatology, 2012, 28(3): 324-327 |
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| Authors: | ZHU Xiuli GUO Qingyu WEN Desheng WANG Jing WU Junzheng |
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| Affiliation: | 1.100039 Beijing,Department of Stomatology,General Hospital of Chinese People’s Armed Police Forces,China;2.School of Stomatology,The Fourth Military Medical University,Xi’an |
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| Abstract: | Objective: To study the expression of matrix metalloproteinase 1(MMP-1) in human salivary gland adenoid cystic carcinoma cell lines with different metastatic potential.Methods: The expression of MMP-1 protein in ACC-2 cell line and its highly metastatic cell clone ACC-M was determined by the methods of immunohistochemistry and western blot.Results: Higher expression of MMP-1 protein was determined in ACC-M cells than in ACC-2 cells.Conclusion: MMP-1 may play a role in the metastasis of human salivary gland adenoid cystic carcinoma. |
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| Keywords: | MMP-1 Human salivary gland adenoid cystic carcinoma Metastasis |
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