| 尿液脱落细胞端粒酶活性测定在膀胱癌术后复发监测中的应用 |
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| 引用本文： | 周文生. 尿液脱落细胞端粒酶活性测定在膀胱癌术后复发监测中的应用[J]. 中华全科医学, 2012, 0(4): 504-505 |
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| 作者姓名： | 周文生 |
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| 作者单位： | 安徽省蚌埠医学院第一附属医院泌尿外科 |
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| 基金项目： | 安徽省教育厅自然科学研究项目(2003kj268) |
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| 摘 要： | 目的探讨尿液脱落细胞端粒酶活性测定在膀胱癌术后复发监测中的价值。方法定期收集60例膀胱癌患者术后3年的尿液,采用PCR-ELISA法检测尿液中脱落细胞端粒酶活性,用以指导膀胱镜检查并确定诊断。结果14例患者的尿液脱落细胞端粒酶活性呈阳性,其中10例确诊复发;而2例复发的患者端粒酶活性呈阴性,尿液脱落细胞端粒酶活性在膀胱癌术后患者中的敏感性和特异性分别为80.0%和87.5%。结论尿液脱落细胞端粒酶活性测定是膀胱癌术后复发检查中的有效手段,可指导有针对性的膀胱镜检查。
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| 关 键 词： | 端粒酶 尿液脱落细胞 术后复发 |
Value of Telomerase Activity in Exfoliated Cells in Urine in Diagnosis of Postoperative Recurrence of Bladder Cancer |
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| ZHOU Wen-sheng. Value of Telomerase Activity in Exfoliated Cells in Urine in Diagnosis of Postoperative Recurrence of Bladder Cancer[J]. Applied Journal Of General Practice, 2012, 0(4): 504-505 |
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| Authors: | ZHOU Wen-sheng |
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| Affiliation: | ZHOU Wen-sheng.Department of Urology,the Frist Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China |
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| Abstract: | Objective To explore the value of telomerase activity in exfoliated cells in urine in the diagnosis of postoperative recurrence of.Methods The urines of 60 patients who have undergone the bladder cancer surgery treatment were collected and the telomerase activity was analyzed by using polymerase chain reaction-enzyme linked immunosorbent assay(PCR-ELISA).The results of cystochromoscopy were compared.Results The telomerase activity was positive in 14 cases,in which 10 cases recurred bladder cancer.The sensitivity and specificity of telomerase activity in urine exfoliated cells were 80% and 87.5%.Conclusion PCR-ELISA assay to detect telomerase activity in urine exfoliated cells is a useful methods in the diagnosis of postoperative recurrence of bladder cancer. |
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| Keywords: | Telomerase Exfoliated cells in urine Postoperative Recurrence |
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