酚妥拉明联合垂体后叶素治疗支气管扩张咯血的疗效观察

目的观察垂体后叶素联合酚妥拉明治疗支气管扩张咯血的疗效。方法将支气管扩张咯血患者60例随机单盲法分为治疗组和对照组各30例,两组在抗感染治疗基础上,均予止咳对症及恰当的体位引流等,对照组予垂体后叶素持续静脉使用,输液速度维持在0.1 U/(kg.h)水平。治疗组在上述应用垂体后叶素以0.1 U/(kg.h)同时加用酚妥拉明以0.08 mg/min持续静脉滴注。对比两组疗效和不良反应。结果治疗组总有效率90%(27/30)高于对照组的83%(25/30),差异有统计学意义(χ2=8.27,P<0.05)。治疗组咯血停止时间平均(3.6±1.3)d,和对照组的(4.7±1.5)d相比亦明显减少,差异有统计学意义(t=3.25,P<0.05)。对照组发现有不同程度的副反应,发生率为46.7%(14/30)。治疗组未出现明显的药物不良反应。结论垂体后叶素和酚妥拉明联用治疗支气管扩张咯血快速高效,不良反应少,值得临床推广。

Curative Effect of Phentolamine Combined Pituitrin for Bronchiectasis with Hemoptysis

Objective To study the curative effect of phentolamine combined with pituitrin in the treatment of bronchietasis with hemoptysis.Methods All 60 cases were randomly divided into treatment group(30 cases,treated with phentolamine combined pituitary vasopressin) and control group(30 cases,treated with pituitary vasopressin).The efficiency and adverse effects were observed.Results The total effective rate was 90%(27/30) in the treatment group and were higher than that(83%,25/30) in the control group(χ2=8.27,P<0.05);Time to stop bleeding was(3.6±1.3)days in treatment group and(4.7±1.5)days in the control group(t=3.25,P<0.05);There was significant difference between them.Conclusion The phentolamine combined pituitary vasopressin,with less adverse reaction,is effective for the bronchodilation with hemoptysis.