异丙酚对失血性休克兔肾脏的保护作用

目的探讨异丙酚对失血性休克肾功能代谢的保护作用及其可能机制。方法建立失血性休克动物模型，选健康新西兰大耳白兔32只随机分为对照组、休克组、灌注组、异丙酚干预组，每组8只。检测血尿素氮、肌酐含量；比色法NSL酸脱氢酶活性、血浆和肾组织乳酸含量。结果血尿素氮、肌酐含量、乳酸脱氢酶活性、血浆和肾组织乳酸含量，休克组、灌注组显著升高，与对照组比较，差异有统计学意义（P〈0．01）。异丙酚干预组各项测定指标的活性、含量均显著降低，与休克组与灌注组比较，差异有统计学意义（P〈0．01）。对照组和异丙酚干预组比较，以上各指标差异均无统计学意义（P〉0．05）。结论失血性休克可引起肾组织明显功能代谢障碍，异丙酚干预后各项测定指标的活性、含量均发生了变化，提示异丙酚对失血性休克肾功能与代谢具有一定的保护作用，为临床应用提供了依据。

Protective effects of propofol on renal function by hemorrhagic shock in New Zealand Rabbits

Objective To investigate the protective effects of propofol on renal function by hemorrhagic shock and the mechanism in rats. Methods A model of hemorrhagic shock in New Zealand Rabbit was established. Thirty-two healthy rabbits were randomly divided into 4 groups （n = 8 each） ： control group, shock group, perfusion group and propofol （pretreatment）group. Blood samples were taken from the femoral vein for determination of levels of blood urea nitrogen（BUN）, creatinine（Cr）, lactic dehydrogenase（LDH） and lactic acid（LD）. LD was detected in renal samples. Results All of the detection indexes were significantly higher in shock group and perfusion group than in control group （P〈0. 01）. However, all of the detection indexes were significantly lower in propofol group than in shock group and perfusion group（P〈0. 01）. There was no significant difference in all of the detection indexes between propofol group and control group（P〈0.05）. Conclusions The renal dysfunction can be caused by hemorrhagic shock. Propofol administration can be of benefit to the renal function during hemorrhagic shock.