川芎嗪联合坎地沙坦酯对高血压早期肾损害合并高尿酸血症的临床观察

目的 观察川芎嗪联合坎地沙坦酯对高血压早期肾损害合并高尿酸血症的影响.方法 将高血压早期肾损害合并高尿酸血症患者48例随机分为治疗组24例,对照组24例.治疗组用坎地沙坦酯8 mg联合川芎嗪160 mg加用生理盐水250ml静脉滴注；对照组仅用坎地沙坦酯8 mg.共观察4周.观察、记录治疗前、治疗后24 h尿微量白蛋白,血尿酸,尿素氮,血肌酐,胆固醇,甘油三酯,血压和药物不良反应.结果 2组均能降低患者尿微量白蛋白及血尿酸,但治疗组下降更加明显（P＜0.01）.结论 川芎嗪联合坎地沙坦酯治疗高血压早期肾损害合并高尿酸血症,能明显降低患者尿微量白蛋白、血尿酸,改善微循环,减轻肾损害,且无明显不良反应.

Clinical research of TMP injection combined with candesartan cilexetil for hypertension-induced early renal damage complicated with hyperuricemia

Objective To observe the effects of TMP injection combined with candesartan cilexetil for hypertension-induced early renal damage complicated with hyperuricemia. Methods Forty-eight patients with hypertension-induced early renal damage complicated with hyperuricemia were randomly divided into the treatment group （n = 24） and the control group （n = 24）. Treatment group was given candesartan cilexetil （8 mg） and intravenous injection of TMP （160 mg ＋ 250 mL normal saline）; the control group was given candesartan cilexetil （8 mg）. The treatment lasted 4 weeks. 24-h urine albumin, uric acid, blood urea nitrogen, serum creatinine, cholesterol, triglycerides, blood pressure and adverse drug reactions were observed and recorded before and after treatment. Results In both groups, urinary albumin and serum uric acid were reduced, but more significant change was found in treatment group （P〈0. 01）. Conclusions TMP combined with Candesartan cilexetil can significantly reduce urine albumin and uric acid, improve microcirculation, alleviate renal damage in the treatment of hypertension-induced early renal damage complicated with hyperuricemia.