混合滥用药物的气相色谱质谱分析

目的 :建立混合滥用药物快速、灵敏检测方法。方法 :采用气相色谱 质谱法 (GC MS)对 11种毒品、药品进行定性定量分析。结果 :苯丙胺类及吗啡在 5 0× 10 - 4- 2 0× 10 - 2 g·ml- 1 范围内线性关系良好 ,检出限分别为 1 0×10 - 4g·ml- 1 和 2 0× 10 - 4g·ml- 1 ;氯胺酮、哌替啶、地西泮、咖啡因、可卡因、马来酸氯苯吡及乙酰替乙氧苯胺线性范围为 5 0× 10 - 6 - 5 0× 10 - 4g·ml- 1 ,检出限为 1 0× 10 - 6 g·ml- 1 和 2 0× 10 - 6 g·ml- 1 。结论 :本方法可用于混合滥用药物组分的快速、准确定性定量分析。

ANALYSIS ON MIXED DRUG OF ABUSE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

Objective: To establish a sensiti ve and rapid method for determination of components of mixed drugs of abuse. Methods: Gas chromatography/mass spectrometry (GC/MS) was used for qualitative and quantitative analysis of the components in mixed drugs of abuse . Results: The calibration of amphetamines and morphine had a good linear relationship in the range of 5.0×10 -4-2.0×10 -2 g·m l -1, the minimal detection limits (LOD) were 1.0×10 -4 g·ml -1 and 2.0×10 -4 g·ml -1, respectively; the linear range of ket amine, pethidine, diazepam, caffeine, cocaine, chlorpheniramine and phe nacetin was 5.0×10 -6-5.0×10 -4 g·ml -1 and the minimal det ection limit were 1.0×10 -6 g·ml -1 and 2.0×10 -6 g·ml -1. Conclusion: The established method can be used for qualitative and quantitative analysis of components of mixed drugs rapidly and accurately.