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| 儿茶素清除O2与·OH的能力 | |
| 引用本文： | 何小解 易著文 田云 卢向阳 党西强 莫双红 杨华彬. 儿茶素清除O2与·OH的能力[J]. 中南大学学报(医学版), 2006, 31(1): 138-140 |
| 作者姓名： | 何小解 易著文 田云 卢向阳 党西强 莫双红 杨华彬 |
| 作者单位： | 中南大学湘雅二医院小儿肾脏病研究室,湖南省小儿肾脏病临床中心,长沙,410011;湖南农业大学,长沙,410128 |
| 基金项目： | 湖南省自然科学基金(02JJY3020);湖南省教育厅重点项目(02A015) |
| 摘 要： | 目的研究儿茶素直接捕获(O-·2)与·OH的能力.方法利用微弱化学发光法检测儿茶素对(O-·2)与·OH的清除能力;利用自旋捕集技术验证儿茶素对(O-·2)与·OH的清除能力.结果儿茶素清除(O-·2)与·OH的IC50分别为6.16,0.59 μg/mL,明显优于甘草提取物、迷迭香提取物、葡萄籽提取物、虎杖提取物及银杏叶提取物.结论供试的几种重要天然植物抗氧化剂中,儿茶素对(O-·2)与·OH的清除能力最强. |
| 关 键 词： | 儿茶素 化学发光 自旋捕集 抗氧化剂 |
| 文章编号： | 1672-7347(2006)01-0138-03 |
| 收稿时间： | 2005-05-20 |
| 修稿时间： | 2005-05-20 |
Ability of catechin toeliminate O |
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,lt,FONT face=. Ability of catechin toeliminate O[J]. Journal of Central South University. Medical sciences, 2006, 31(1): 138-140 |
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| Authors: | < FONT face= |
| Affiliation: | Laboratory of Pediatric Nephrology, Institute of Pediatrics, Second Xiangya Hospital, Central South University, Hunan Clinic Center of Pediatric Nephrology, Changsha. hexj7150@163.com |
| Abstract: | OBJECTIVE: To investigate the eliminating ability of catechin to eliminate O2-* and *OH. METHODS: The ability of catechin to clear away O2-* and *OH was respectively measured by faintness chemiluminescence and spin trapping assay. RESULTS: IC50 that catechin eliminated O2-* and *OH was 6.16, 0.59 g/mL respectively, and the eliminating ability of catechin was much stronger than that of the extract from liquorice, rosemary, grape pip, giant knotweed and ginkgo leaf. CONCLUSION: Compared with several important natural plants of antioxidants, the eliminating ability of cathechin is the best. |
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