CDFI检测肾血流PSV、EDV改变与CPB术后AKI相关性研究

目的：本研究运用临床无创的彩色多普勒血流显像作为研究手段,探讨肾血流PSV、EDV改变与体外循环（CPB）手术肾功能损害的可能关系.方法：对14例心脏病在实施CPB心脏直视手术前、术后1 h、2h、4 h、8h、16h、24 h,运用彩色多普勒血流显像分别监测各时点肾主动脉、肾段动脉PSV 、EDV,并同时检测肾功能尿素氮（Urea）、尿酸（UA）、肌酐（Crea）,对所有数据进行统计分析.结果：术后1h肾主动脉、肾段动脉PSV与术前比较增高,术后4 h、16 h、24 h肾主动脉、肾段动脉PSV与术后1h比较减低.术后2h肾主动脉EDV与术前比较增高,术后4 h、8 h、16 h、24h肾主动脉EDV与术后2h比较减低,术后4h肾段动脉EDV与术后1h比较减低;肾血流EDV与肾功能指标Urea、UA、Crea呈负相关.结论：CPB术后肾主动脉、肾段动脉EDV与Urea、UA、Crea存在负相关,肾主动脉、肾段动脉EDV可作为评估CPB术后AKI发生的指标.

The correlation research between the renal blood flow PSV,EDV monitored by CDFI and AKI after CPB

Objective：In this study,to explore the relationship between the renal blood flow peak systolic velocity（PSV）,end diastolic velocity （EDV）,detected by CDFI,and the acute kidney injury （AKI） caused by cardiopulmonary bypass（CPB）.Methods：Fourteen cases with heart disease were accepted.The main renal artery and renal segmental artery PSV,EDV of all cases were monitored by CDFI at preoperative and postoperative 1 h,2 h,4 h,8 h,16 h,24 h.The renal blood urea nitrogen （Urea）,uric acid （UA）,creatinine （Crea）,were detected at the same time.All data were performed for statistical analysis.Results：The main renal artery and renal segmental artery PSV was higher at 1 h postoperative time point than that at the preoperative and 4 h,16 h,24 h postoperative time points.The renal aorta EDV was higher at the postoperative 2 h than that at the preoperative and postoperative 4 h,8 h,16 h,24 h.The renal segmental artery EDV was lower at the postoperative 4 h than that at postoperative 1 h.The renal blood flow EDV was negatively correlated with the renal function parameters：Urea,UA,Crea.Conclusion：The main renal artery,renal segmental artery EDV and the Urea,UA,Crea had negative correlation after CPB.The EDV may be used as an evaluation index to assess AKI after CPB.