激素、雷公藤、川芎嗪治疗老年原发性肾病综合征疗效观察

目的:探讨激素合用雷公藤、川芎嗪治疗老年原发性肾病综合征的疗效。方法:将42例老年原发性肾病综合征患者随机分成两组,其中联用激素、雷公藤、川芎嗪治疗组22例,单用激素对照组20例,分别观察其缓解率及复发率,检测两组在治疗前后血清白蛋白、24 h尿蛋白定量、血脂及肾功能等指标的变化。结果:治疗组总缓解率为90.9%,复发率为20%。对照组总缓解率为60%,复发率为41.7%,两组差异有统计学意义(P<0.05)。两组治疗后血清白蛋白、24 h尿蛋白定量、血脂指标均改善,但治疗组比对照组改善更为明显。结论:激素合用雷公藤、川芎嗪治疗老年原发性肾病综合征疗效优于单用激素治疗。

Observation on the therapeutic effect of the prednisone, tripterygium wilfordii, ligustrazin in old age primary nephrotic syndrome

Objective:To study the therapeutic effect of the prednisone,tripterygium wilfordii and ligustrazin in old patients with primary nephrotic syndrome.Methods:Fortytwo old age primary nephrotic syndrome patients were randomly divided into two groups.The treated group including 22 patients was treated by prednisone,tripterygium wilfordii and ligustrazin,and the control group including 20 patients was treated only by prednisone.The total relieving rate and recurrence rate were observed in the two groups,and the changes of serem albumin,24 hours urinary protein,plasma lipid and renal function were observed on both pretreatment and post-treatment groups.Result:The total relieving rate in treatment group and control group were 90.9% and 60% respectively,the recurrence rate were separately 20% and 41.7%.There were significantly difference in the two groups(P<0.05).After treatment the indexes of serum albumin,24 hours urinary protein,lipid and renal function were ameliorated in two groups,but the degree of amelioration in the treated group was higher than that in the control group.Conclusion:The therapeutic of the prednisone,tripterygium wilfordii and ligustrazin in old age primary nephrotic syndrome could increase the effect better than the therapeutic of prednisone.