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| 鼻咽癌染色体7q32区域微缺失的研究 | |
| 引用本文： | 唐湘娜,阳剑波,邓龙文,江宁,周鸣,曾朝阳,谢奕,谭国林,邱元正,李桂源.鼻咽癌染色体7q32区域微缺失的研究[J].中华医学遗传学杂志,2000,17(3):153-156. |
| 作者姓名： | 唐湘娜 阳剑波 邓龙文 江宁 周鸣 曾朝阳 谢奕 谭国林 邱元正 李桂源 |
| 作者单位： | 1. 410078,长沙,湖南医科大学肿瘤研究所 2. 410078,长沙,湖南医科大学附属第三医院耳鼻喉科 3. 410078,长沙,湖南医科大学湘雅医院耳鼻喉科 |
| 基金项目： | 国家高技术研究发展计划(863计划)，国家自然科学基金 |
| 摘 要： | 目的 进一步明确鼻咽癌染色体７ｑ３２的Ｄ７Ｓ５００－Ｄ７Ｓ４９５附近区域高频率等位基因缺失的范围。方法 采用更高密度的微卫星标记位点，分析３０个鼻咽癌病例等位基因杂合性缺失的情况。结果 ３０例 患者中有１９例（６３．３％）存在杂合性缺失；Ｄ７Ｓ５００－Ｄ７Ｓ５０９－Ｄ７Ｓ４９５是高频率缺失集中的区域，共同缺失区在Ｄ７Ｓ５０９附近。结论 Ｄ７Ｓ５０９附近可能存在与鼻咽癌发病相关的抑癌基因。 |
| 关 键 词： | 鼻咽癌 染色体7q32 等位基因缺失 抑癌基因 |
Detailed allelic loss mapping on 7q32 in nasopharyngeal carcinoma |
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| TANG Xiangna,YANG Jianbo,DENG Longwen,JIANG Ning,ZHOU Ming,ZENG Zhaoyang,XIE Yi,TAN Guolin,QIU Yuanzheng,LI Guiyuan.Detailed allelic loss mapping on 7q32 in nasopharyngeal carcinoma[J].Chinese Journal of Medical Genetics,2000,17(3):153-156. | |
| Authors: | TANG Xiangna YANG Jianbo DENG Longwen JIANG Ning ZHOU Ming ZENG Zhaoyang XIE Yi TAN Guolin QIU Yuanzheng LI Guiyuan |
| Institution: | Cancer Research Institute, Hunan Medical University, Changsha, Hunan, 410078 P. R. China. ligy@public.cs.hn.cn |
| Abstract: | Objective The present research group had found high frequency of loss of heterozygosity (LOH) of D7S500 D7S495 on chromosome band 7q32 in nasopharyngeal carcinoma, this study was conducted to further find the deletion region. Methods Higher density of loci on 7q32 in 30 tumors was studied by using microsatellite analysis. Results The frequency of LOH was 63.3%. The highest frequency of LOH was identified at the loci of D7S500 D7S509 D7S495, among which a common deletion of D7S509 was found.Conclusion A putative tumor suppressor gene may be present around D7S509. |
| Keywords: | nasopharyngeal carcinoma chromosome 7q32 allelic loss tumor suppressor gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |