| 黏着斑激酶在喉癌中的表达及临床意义 |
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| 引用本文： | 于锋,董玉礼,焦粤龙,张浩亮,黎小冰,梁子健,谢佳. 黏着斑激酶在喉癌中的表达及临床意义[J]. 临床耳鼻咽喉头颈外科杂志, 2004, 18(3): 149-151 |
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| 作者姓名： | 于锋 董玉礼 焦粤龙 张浩亮 黎小冰 梁子健 谢佳 |
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| 作者单位： | 广州市耳鼻咽喉头颈外科医院耳鼻咽喉-头颈外科,广州,510620;蚌埠医学院附属医院耳鼻咽喉科 |
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| 基金项目： | 安徽省教育委员会科研计划资助项目 (No :99jlo14 9) |
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| 摘 要： | 目的 :探讨黏着斑激酶 (FAK)在喉癌及癌旁组织中的表达及其与喉癌的临床分期、生存率、转移等生物学行为的关系。方法 :应用免疫组织化学法检测 10 0例喉癌及 6 0例癌旁组织石蜡标本中FAK的表达水平。结果 :FAK在喉癌中的表达明显高于癌旁组织 (P <0 .0 5 ) ;Ⅲ、Ⅳ期表达较Ⅰ、Ⅱ期高 (P <0 .0 5 ) ;FAK表达较强阳性和强阳性者 3、5年生存率分别为 76 .9%(5 0 /6 5 )和 6 1.5 %(4 0 / 6 5 ) ,而阴性和弱阳性者 3、5年生存率分别为 97.1%(34/ 35 )和 88.6 %(31/ 35 ) ,其差异均有统计学意义 (P <0 .0 1)。结论 :FAK的表达可作为了解喉癌肿瘤细胞生物学行为、转移及预后判断的一种较有价值的病理指标。
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| 关 键 词： | 喉肿瘤 黏着斑激酶 免疫组织化学 |
| 文章编号： | 1001-1781(2004)03-0149-03 |
| 修稿时间： | 2003-05-22 |
Expression of focal adhesion kinase in laryngeal carcinoma |
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| YU Feng DONG Yuli JIAO Yuelong ZHANG Haoliang LI Xiaobing LIANG Zijian XIE Jia. Expression of focal adhesion kinase in laryngeal carcinoma[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2004, 18(3): 149-151 |
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| Authors: | YU Feng DONG Yuli JIAO Yuelong ZHANG Haoliang LI Xiaobing LIANG Zijian XIE Jia |
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| Affiliation: | Department of Otolaryngology-Head and Neck Surgery, Guangzhou Hospital of Otolaryngology-Head and Neck Surgery, Guangzhou, 510620, China. |
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| Abstract: | OBJECTIVE: To evaluate the pattern of FAK expression in laryngeal squamosa cell carcinoma and non-carcinoma tissue. METHOD: Expression of FAK was examined in 100 specimens with laryngeal squamosa cell carcinoma and 60 specimens with non-carcinoma, in which 8 cases were in stage I, 23 cases in stage II, 38 cases in stage III and 31 cases in stage IV. RESULT: The staining of FAK was stronger in laryngeal squamous cell carcinomas than in the cell of non-carcinoma areas. The cancers with lymphnode metastasis had more FAK protein than the cancers with out lymph node metastasis. Survival rate at 3 and 5 years was 76.9%(50/65) and 61.5%(40/65) respectively for positive staining group of FAK, compared to 97.1%(34/35) and 88.6% (31/35) respectively for negative staining group. CONCLUSION: The results in the report show that the level of FAK expression might be a valuable marker for carcinogeneandsis and the progression of carcinoma. |
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| Keywords: | Laryngeal neoplasms Focal adhesion kinase Immunohistochemistry |
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