糖尿病足患者发生多重耐药菌感染的危险因素相关分析

目的：研究糖尿病足患者感染的多重耐药菌（MDRMs）的分布、药物敏感性，以及感染MDRMs的危险因素。方法选取2015年1月至2016年6月在茂名市人民医院因糖尿病足感染住院的所有患者为研究对象，回顾性地分析他们的临床资料和病原菌培养及药敏结果。然后以36例感染MDRMs的糖尿病足患者为病例组，其余66例为对照组，分析MDRMs感染的危险因素。结果病例组分离出39株MDRMs ，主要的MDRMs分别是金黄色葡萄球菌（57．1％）、铜绿假单胞菌（21．4％）、大肠埃希菌（14．3％）。对两组相关因素对比分析可知，既往使用抗菌药物、住院次数、住院天数差异有统计学意义（ P＜0．05）。结论既往使用抗菌药物、住院次数、住院天数差异为糖尿病足患者多重耐药感染的危险因素。

Risk factors for multiple drug resistant bacteria infection in diabetic foot patients

Objective To investigate the distribution of features and the present condition of drug resistance as well as the risk factors for infection of the diabetic foot with multi-drug resistant microorganisms(MDRMs) .Methods Amongst 102 diabetic pa-tients with evidence of infection of the foot who presented to Maoming People′ Hospital between January 2015 and June 2016 ,we choose 36 patients with infection of MDRMs as case group and 66 patients without infection of MDRMs as control group to investi-gate risk factors that might be predictive of multi-antibiotic resistance of the infecting organism .Results 39 MDRMs strains were i-solated from 36 patients in the case group ,among which the top three were Staphylococcus aureus (57 .1% ) ,Pseudononas aerugino-sa (21 .4% ) ,E .col (14 .3% ) .Previous antibiotic therapy ,frequency of hospitalization above 2 times a year ,and duration of hospital stay were significant risk factors for infections with multidrug resistant microorganisms (P<0 .05) .Conclusion Previous antibiotic therapy ,frequency of hospitalization above 2 times a year ,and duration of hospital stay were closely related with infections of dia-betic foot wound with multidrug resistant microorganisms .