Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance |
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| Authors: | Ryan K. Shields M. Hong Nguyen Ellen G. Press Cornelius J. Clancy |
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| Affiliation: | aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;bXDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA;cVA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA |
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| Abstract: | FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure (P = 0.01), breakthrough infections (P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida. |
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