Effects of tiletamine on spinal cord synaptic transmission

The effect of tiletamine on synaptic transmission was studied in the dorsal root—ventral root preparation of unanesthetized spinal cats. Tiletamine, 10–20 mg/kg, reduced the evoked monosynaptic response of motoneurons with only slight depression on polysynaptic responses. It also augmented the post-tetanic potentiation (PTP) of monosynaptic responses, which may be related to its seizure-producing property. The effect of tiletamine developed within 5 min after i.v. administration and lasted for more than 1 hr.