| 作为乙肝疫苗的新型结构肽的设计与合成 |
| |
| 引用本文： | 孙颖,王德心,鲁桂琛. 作为乙肝疫苗的新型结构肽的设计与合成[J]. 药学学报, 1996, 31(3): 186-190 |
| |
| 作者姓名： | 孙颖 王德心 鲁桂琛 |
| |
| 作者单位： | 中国医学科学院中国协和医科大学药物研究所 |
| |
| 摘 要： | 在乙肝病毒表面抗原结构研究的基础上,自行设计了三个新型结构的肽疫苗,采用Boc化学和Fmoc化学相匹配的策略,应用固相肽逐步合成法合成,产物经氨基酸分析鉴定。
|
| 关 键 词： | 乙肝疫苗 Boc/Fmoc 固相肽合成 |
| 收稿时间： | 1995-04-28 |
DESIGN AND SYNTHESIS OF NOVEL PEPTIDES AS HEPATITIS B VACCINE |
| |
| Y Sun,DX Wang and GS Lu. DESIGN AND SYNTHESIS OF NOVEL PEPTIDES AS HEPATITIS B VACCINE[J]. Acta pharmaceutica Sinica, 1996, 31(3): 186-190 |
| |
| Authors: | Y Sun DX Wang GS Lu |
| |
| Abstract: | S Three peptides as hepatitis B vaccine candidates were designed according to aprinciple in which high-density multiple segments of HBV were linked covalently instead of conjugatinga proteinous earrier.Ahybrid MAP(multiple antigen peptide)structure with lysine-tree scaffoldingwas assembled in some of these peptides. All target peptides were synthesized by stepwise solid-phaseprocedure with Boc/Bzl and Boc/Bzl-Fmoc/tBu matching protocols.The structures of the preductswere confirmed by amino acid analysis. |
| |
| Keywords: | Hepatitis B vaccine Boc/Fmoc SPPS |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
