Subclinical Inflammation in Heart Failure: A Neutrophil Perspective |
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| Authors: | Branka Vulesevic Martin G. Sirois Bruce G. Allen Simon de Denus Michel White |
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| Affiliation: | 1. Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada;2. Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Québec, Canada;3. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Québec, Canada;4. Faculty of Pharmacy, Université de Montréal, Montreal, Québec, Canada |
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| Abstract: | Although it is widely recognized that inflammation plays a critical role in the development and pathology of heart failure (HF), very little is known about the involvement of one of the most abundant immune cells in the blood, a primary immune response cell: the neutrophil. This review summarizes the current literature on the role of subclinical inflammation, with a focus on the neutrophil in the pathophysiology of the HF syndrome. Some emerging therapeutic strategies are also discussed. |
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| Keywords: | Corresponding author: Dr Michel White, Montreal Heart Institute, 5000 Belanger Street, Montreal, Québec H1T 1C8, Canada. Tel.: +1-514-376-3330 fax: +1-514-376-1355. |
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