FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties |
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| Authors: | Nishihara Y Tsujii E Yamagishi Y Kino T Hino M Yamashita M Hashimoto S |
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| Affiliation: | Fermentation Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Nishikasugai-gun, Aichi, Japan. |
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| Abstract: | FR191512, a novel polyphenolic compound, inhibited the infectivity of influenza A virus in Madin-Darby canine kidney (MDCK) cells in vitro. Furthermore, FR191512 showed good in vivo anti-influenza activity in a mouse model of intranasal infection with influenza A virus. The cytotoxic activity of FR191512 against MDCK cells was very weak. |
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