| 马蔺子甲素全合成工艺的研究 |
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| 引用本文： | 陶遵威,解红武,黄佳慰,刘惠芝.马蔺子甲素全合成工艺的研究[J].中国药物化学杂志,2002,12(3):149-151,178. |
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| 作者姓名： | 陶遵威 解红武 黄佳慰 刘惠芝 |
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| 作者单位： | 1. 天津医药科学研究所,天津,300070
2. 天津燕化新材料有限公司,天津,300385 |
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| 摘 要： | 以邻丁香酚为原料，经苄基保护酚羟基、臭氧制备醛、缩合、加氢还原并脱苄基保护基、硅烷保护酚羟基、缩合、脱保护基、催化氧化八步反应合成了马蔺子甲素。使反应的成本比原路线有了很大的降低。总收率也有了一定的提高。
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| 关 键 词： | 马蔺子甲素 合成 抗肿瘤 |
| 文章编号： | 1005-0108(2002)03-0149-03 |
Study on the total synthetic technology of pallasone A |
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| TAO Zun wei ,XIE Hong wu ,HUANG Jia wei ,LIU Hui zhi.Study on the total synthetic technology of pallasone A[J].Chinese Journal of Medicinal Chemistry,2002,12(3):149-151,178. |
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| Authors: | TAO Zun wei XIE Hong wu HUANG Jia wei LIU Hui zhi |
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| Institution: | TAO Zun wei 1,XIE Hong wu 1,HUANG Jia wei 2,LIU Hui zhi 1 |
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| Abstract: | Pallasone A was synthesized from 6 allyl 2 methoxyphenol via protection of phenol hydroxy,made aldehyde by ozone condensation,hydrogenization reduction,deprotection and protection of phenol hydroxy with silica alkyl,deprotection and catalytic oxidation.The cost of synthesis(1)was lower than the former one,and the yield was definitely increased. |
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| Keywords: | pallasone A synthesis antitumor |
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