Nuclear expression of onco-suppressors nm23-H1 and maspin are associated with lower recurrence rate in laryngeal carcinoma |
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Authors: | Gino Marioni Giancarlo Ottaviano Cosimo de Filippis Elena Fasanaro Benedetto Randon Stefano Meneghesso Luciano Giacomelli Laura Astolfi Stella Blandamura |
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Affiliation: | 1. Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Padova, Italy;2. Department of Neuroscience DNS, Audiology Unit, University of Padova, Treviso, Italy;3. Radiotherapy Unit, Veneto Institute of Oncology IOV–IRCCS, Padova, Italy;4. Department of Medicine DIMED, University of Padova, Padova, Italy;5. Department of Neuroscience DNS, Bioacoustics Research Laboratory, University of Padova, Padova, Italy |
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Abstract: | PurposeThe main aim of the study was to preliminarily investigate the possibly related role of nuclear onco-suppressors maspin and nm23-H1, a metastasis suppressor, in laryngeal squamous cell carcinoma (LSCC).Materials and methodsMaspin expression pattern and nuclear nm23-H1 expression were ascertained in 62 consecutive LSCCs.ResultsRecurrence rate was significantly lower in patients with a nuclear maspin pattern of expression; nuclear nm23-H1 expression was significantly lower in patients who experienced disease recurrence. Disease free survival (DFS) was significantly longer in patients with maspin nuclear pattern or with nuclear nm23-H1 expression ≥10%. A significant association was found between nuclear nm23-H1 expression and maspin pattern of expression in LSCC. KNN discriminant analysis considered N status, maspin sub-cellular localization and nuclear nm23-H1 expression. The selected variables' accuracy in terms of relapse was 82%. Positive predictive accuracy was 100%, and negative predictive accuracy 79%.ConclusionsNuclear nm23-H1 expression and maspin pattern, also in association, show promise as recurrence indicators in LSCC. Further studies are needed to shed more light on the nm23-H1 mechanism of action in LSCC and thus find ways to restore nm23-H1 loss. These preliminary findings suggest that re-activating maspin functions might represent an important goal in the treatment of advanced LSCC. |
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Keywords: | Laryngeal squamous cell carcinoma Nuclear Tumor suppressors nm23-H1 Maspin |
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