Modification of blood coagulation by the anti-arrhythmia drug prajmalium bitartrate in vivo |
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| Authors: | H Riess F Bauer E Hoffmann G Steinbeck E Hiller |
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| Affiliation: | Medizinische Kliniken III, Ludwig-Maximilians-Universit?t, München. |
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| Abstract: | We studied the effects of prajmaliumbitartrate (PBT, Neo-Gilurytmal, Giulini Pharma, Hannover, FRG), an antiarrhythmic drug on some parameters of blood coagulation in patients. PBT, 20 mg given three times a day, significantly prolonged template bleeding time and ex vivo thrombus formation time in a modified Chandler's loop. Ex vivo platelet aggregation using different agonists and tests of the plasmatic coagulation system remained unchanged. |
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