Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence |
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| Authors: | Strauss O J Warren R M Jordaan A Streicher E M Hanekom M Falmer A A Albert H Trollip A Hoosain E van Helden P D Victor T C |
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| Affiliation: | DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/ MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa. |
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| Abstract: | The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations. |
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