Phospholipid composition of liver mitochondria in experimental hemorrhagic shock

Heparin used as an anticoagulant in modeled hemorrhagic shock decreases the phosphatidylcholine and increases the phosphatidylethanolamine contents in the mitochondria. Accumulation of lysophosphatidylcholine in whole mitochondria and their inner membrane is observed in hemorrhagic shock. At the same time, hemorrhagic shock decreases phosphatidylcholine content in the inner and outer mitochondrial membranes and increases phosphatidylethanolamine content in the outer membranes. Modification of phospholipid composition of mitochondrial membranes is a mechanism responsible for impaired energy production in liver mitochondria in hemorrhagic shock. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 43–45, July, 1997