| 肝病患者血清抗凝血酶Ⅲ、前白蛋白的变化研究及其意义 |
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| 引用本文： | 解渝,张芝兰.肝病患者血清抗凝血酶Ⅲ、前白蛋白的变化研究及其意义[J].医学理论与实践,2003,16(8):886-887. |
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| 作者姓名： | 解渝 张芝兰 |
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| 作者单位： | 1. 扬州大学医学院病理生理教研室,江苏省扬州市,225001
2. 江苏省镇江市东吴医院内科 |
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| 摘 要： | 目的:通过对各类肝病血清抗凝血酶-Ⅲ含量、活性以及前白蛋白的检测,并分析比较,探讨上述指标在反映肝脏受损程度上的诊断价值及临床意义。方法:AT-Ⅲ抗原(AT-Ⅲ:Ag)测定用火箭电泳法,AT-Ⅲ活性(AT-Ⅲ:A)测定有凝血酶凝胶空斑法,前白蛋白测定用速率散射比浊法。结果:各肝病组两项指标与健康对照组比较均明显下降(P<0.01),前白蛋白下降更为显著,各肝炎组间差异也比AT-Ⅲ显著(P<0.01),特别为急性肝炎。结论:血清前白蛋白含量的变化能早期准确地反映肝细胞受损程度及肝脏储备功能,对于各类肝病前白蛋白的检测比抗凝血酶-Ⅲ更敏感,是一项十分有价值的良好指标。
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| 关 键 词： | 抗凝血酶-Ⅲ 前白蛋白 肝炎 |
| 修稿时间： | 2003年2月23日 |
Clinical Significance of Concentration of Serum AT-Ⅲ and Prealbumin in Patients with Hepatic Disease |
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| XIE Yu,ZHANG Zhilan.Clinical Significance of Concentration of Serum AT-Ⅲ and Prealbumin in Patients with Hepatic Disease[J].The Journal of Medical Theory and Practice,2003,16(8):886-887. |
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| Authors: | XIE Yu ZHANG Zhilan |
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| Institution: | XIE Yu,ZHANG Zhilan. Department of Pathophysiology of Medical College,Yangzhou University,Jiangsu Province 225001 |
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| Abstract: | Objective:To discuss the clinical significance and mechanism of the level of serum AT-Ⅲand prealbumin (PA) in patients with hepatic disease. Methods:Serum AT-Ⅲ antigen (AT-Ⅲ Ag) level was determined by the method of rocket electrophore-sis,AT-3Ⅲ activity( AT-Ⅲ :A) was determined by thrombase-gel-spot method, and the serum PA was determined by rate nephelome-try. Results:The levels of serum ATⅢ and PA were lower in each abnomal groups than those in normal control group ( P < 0.01) , the level of PA decreased more significantly than the level of serum AT-Ⅲ (P < 0.01) ,especially in the group with acute hepatitis. Conclusion: The change of the level of PA can express the damage degree of hepatic cell in early stage and can express the reservation function of liver. This parameter is more sensitivity than that of AT- Ⅲ . So determination of serum PA is very valuable. |
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| Keywords: | AT-Ⅲ Prealbumin Hepatitis |
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