脂源性细胞因子与子痫前期关系的研究

目的:探讨子痫前期(PE)患者血清脂源性细胞因子(脂联素和瘦素)水平的变化及其意义。方法:以53例子痫前期孕妇为研究组(其中轻度子痫前期32例、重度子痫前期21例),20例同期分娩的正常孕妇为对照组。采用ELISA法检测血清脂联素和瘦素水平。同时检测血清甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果:(1)轻度、重度子痫前期患者血清脂联素水平分别为8.88±4.67μg/m l及5.14±2.79μg/m l,明显低于对照组11.61±2.90μg/m l,差异有统计学意义(P<0.01)。而轻度、重度子痫前期患者血清瘦素水平为21.79±15.19ng/m l及27.27±18.38ng/m l,明显高于对照组的12.35±6.51ng/m l,差异有统计学意义(P<0.05,P<0.01),(2)子痫前期患者血清脂联素与TG、TC、LDL-C、HDL-C均显著相关(r分别为-0.658、-0.624、-0.419、0.461),瘦素水平也与上述指标显著相关(r分别为0.534、0.707、0.418、-0.513),(3)子痫前期患者血清脂联素及瘦素水平呈高度负相关(r=-0.760,P<0.01)。结论:脂联素、瘦素等脂源性细胞因子在PE的发病中可能起一定的作用。

Study of relationship between adipocytokine and preeclampsia

Objective:To explore the role of adipocytokine,adiponectin and leptin in the pathogenesis of preeclampsia(PE).Methods:The serum levels of adiponectin and leptin were measured using the enzyme-linked immunosorbent assay in 53 preeclampsia(PE)patients and 20 normal pregnant women.Seventy-three women were divided into three groups:group A consisted of 20 normal pregnant women(NPW);group B consisted of 32 women with mild pre-eclampsia(MPE);and group C consisted of 21 women with severe pre-eclampsia(SPE).Results:The serum levels of adiponectin in women with MPE or SPE were significantly lower(8.88±4.67μg/ml,5.14±2.79μg/ml,respectively) than those in NPW(11.61±2.90μg/ml;P<0.01,P<0.01,respectively).While the serum levels of leptin in women with MPE or SPE were significantly higher than those in NPW(MPE:21.79±15.19ng/mL vs 12.35±6.51ng/ml,P<0.05;SPE:27.27±18.38ng/ml vs 12.35±6.51ng/ml,P<0.01).In the preeclamptic women serum levels of triglycerides(TG),total cholesterol(TC) and low-density lipoprotein-cholesterol(LDL-C) were significantly increased(P<0.01),while high-density lipoprotein-cholesterol(HDL-C)were significantly decreased than those in normal pregnant women(P<0.01).Serum levels of adiponectin were correlated significantly with TG,TC,and LDL-C,HDL-C in pre-eclamptic women(r=-0.658,P<0.01;r=-0.624,P<0.01;r=-0.419,P<0.05;r=0.461,P<0.05,respectively).In addition,serum levels of leptin were significantly correlated with the serum levels of TG,TC,and LDL-C,HDL-C in pre-eclamptic women(r=0.534,P<0.05;r=0.707,P<0.01;r=0.418,P<0.05;and r=-0.513,P<0.01,respectively).There was a negative correlation between the serum levels of adiponectin and leptin in preeclamptic women(r=-0.760,P<0.01).Conclusion:Adiponectin and leptin may be involved in the pathogenesis of PE.Moreover,reduced serum concentrations of adiponectin and elevated leptin are associated with the development of this disease.