VEGF对良恶性心包积液的鉴别诊断价值

目的：探讨VEGF在心包积液病因鉴别诊断中的临床应用价值。方法采用ELISA法，检测34例恶性心包积液与25例非恶性心包积液中VEGF水平，比较良、恶性心包积液中VEGF水平差异。结果恶性心包积液中VEGF水平明显高于非恶性心包积液，当V EG F＞1908 pg／m l ，对恶性心包积液的诊断敏感性及特异性为88％和83.3％。结论恶性心包积液中VEGF水平明显增高，VEGF可作为良恶性心包积液的鉴别诊断的标志物。

The value of VEGF in the diagnosis of pericardial effusion

Objective To explore the clinical value of VEGF in the differential diagnosis of pericardial effusion .Methods U‐sing an enzyme‐linked immunosorbent assay ,we assessed pericardial VEGF levels in patients with malignant pericardial effusion (n=34) ,in patients with nonmalignant pericardial effusion (n=25) .Results VEGF pericardial levels in malignant pericardial effusion were significantly higher compared with VEGF in nonmalignant effusion .Pericardial VEGF levels ≥1 908 pg/ml had 88% sensitivity and 83.3% specificity for the recognition of malignant pericardial effusion in patients with malignant pericardial effusion .Conclusion VEGF levels were significantly higher in malignant pericardial effusion .VEGF in pericardial effusion of‐fers potential as a diagnostic tool to discriminate malignant from benign effusions .