辛伐他汀的调脂及抗动脉粥样硬化作用

采用食饵性兔动脉粥样硬化为模型 ,以舒降之为阳性对照药 ,研究辛伐他汀的调脂及抗动脉粥样硬化作用。将 5 6只雄性新西兰兔 (体重 1.96± 0 .16kg)随机分为对照组 (颗粒饲料 12 0～ 15 0g d ,n =14 )、动脉粥样硬化模型组 [颗粒饲料 +胆固醇 0 .5g (kg·d) ,n =14 ]、舒降之组 [颗粒饲料 +胆固醇 +舒降之片 5mg (kg·d) ,n =14 ]和辛伐他汀组 [颗粒饲料 +胆固醇 +辛伐他汀片 5mg (kg·d) ,n =14 ]。在实验前、实验第 8、12周末分别测定血清总胆固醇和甘油三酯 ,并分别处死 7只兔取主动脉染色测定主动脉粥样硬化斑块面积。结果发现 ,与对照组相比 ,第8、12周末时动脉粥样硬化模型组血清总胆固醇和甘油三酯均显著增高 ,总胆固醇第 8周末为 14 .86± 4 .15mmol L ,第 12周末时为 18.8± 7.6 8mmol L ;甘油三酯第 8周末为 1.83± 0 .4 9mmol L ,第 12周末时为 2 .5 9± 0 .6 3mmol L。第8、12周末时对照组主动脉粥样硬化斑块面积均为零 ,而动脉粥样硬化模型组主动脉粥样硬化斑块面积分别为 35 .2 9%± 9.4 1%和 4 2 %± 9.6 9% ;辛伐他汀组和舒降之组血清总胆固醇和甘油三酯及主动脉粥样硬化斑块面积均显著低于同期动脉粥样硬化模型组 (P <0 .0 1) ,且该两组同期总胆固醇和甘油三酯及主动脉粥样硬化斑块面

An Experimental Study of the Effects of Domestic-Simvastatin on Lowering Serum Lipid and Anti-Atherosclerosis

Aim The purpose of this study was to compare the lipid lowering and anti atherosclerosis efficacy of homemade Simvastatin with Zocor (Simvastatin). Methods 56 rabbits were randomized into four groups. One group was fed with regular chow and did not receive treatments (served as normal control group). The second group was fed with cholesterol enriched diet and served as atherosclerosis group (As group). The other two groups were fed with the cholesterol enriched diet in conjunction with either domestic simvastatin or Zocor in a daily oral dose (domestic Simvastatin group and Zocor group respectively). The hypolipidemic and anti atherosclerosis effect of the above treatments was examined by estimating the levels of serum total cholesterol (TC) and triglycerides (TG). The extent of aortic atherosclerosis was measured by planimetry of the sudanophilic area. Results At the end of 8 and 12 week treatment, levels of TC and TG in As group were increased significantly compared with normal control group at the same phase. The histopathological examination revealed marked alteration in aortic wall with the appearance of large multiple atheromatous plaques in As group, domestic Simvastatin group and Zocor group after treatment, but both the domestic Simvastatin group and the Zocor group were significantly less than that in As group (P<0.01). The total lipids lowering effective rate and anti atherosclerosis efficacy of domestic simvastatin group was equal to Zocor group. Conclusion homemade Simvastatin is an effective medicine for the treatment of hypercholesterolemia and atherosclerosis.