| 广西鸡屎藤的化学成分研究 |
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| 引用本文： | 胡海清,韩贺东,林燕,陈练红,王晓玲.广西鸡屎藤的化学成分研究[J].中国中药杂志,2013,38(16):2657-2660. |
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| 作者姓名： | 胡海清 韩贺东 林燕 陈练红 王晓玲 |
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| 作者单位： | 西南民族大学 少数民族药物研究所, 四川 成都 610041;西南民族大学 少数民族药物研究所, 四川 成都 610041;西南民族大学 少数民族药物研究所, 四川 成都 610041;西南民族大学 少数民族药物研究所, 四川 成都 610041;西南民族大学 少数民族药物研究所, 四川 成都 610041 |
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| 基金项目： | 人力资源与劳动保障部出国留学人员科研启动基金项目;西南民族大学2013年研究生创新型科研项目(CX2013SZ29) |
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| 摘 要： | 利用硅胶柱色谱、ODS 柱色谱等色谱技术对广西鸡屎藤Paederia pertomentosa 全草95%乙醇浸提物进行分离纯化,共得到5个化合物,根据理化数据和波谱数据鉴定化合物的结构分别为1, 2-二甲氧基-3,4-二羟基蒽醌,命名为鸡屎藤蒽醌(1)、鸡屎藤苷(2)、去乙酰车叶草苷酸甲酯(3)、鸡屎藤酸(4)、鸡屎藤酸甲酯(5)。其中,化合物 1 为新化合物,并对大肠杆菌和金黄色葡萄球菌有明显抑制作用,化合物 2~5均为首次从广西鸡屎藤中分离得到。
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| 关 键 词： | 茜草科 广西鸡屎藤 化学成分 环烯醚萜 鸡屎藤蒽醌 抗菌活性 |
| 收稿时间： | 3/8/2013 12:00:00 AM |
Chemical constituents of Paederia pertomentosa |
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| HU Hai-qing,HAN He-dong,LIN Yan,CHEN Lian-hong and WANG Xiao-ling.Chemical constituents of Paederia pertomentosa[J].China Journal of Chinese Materia Medica,2013,38(16):2657-2660. |
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| Authors: | HU Hai-qing HAN He-dong LIN Yan CHEN Lian-hong and WANG Xiao-ling |
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| Institution: | Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041, China;Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041, China;Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041, China;Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041, China;Ethnic Pharmaceutical Institute, Southwest University for Nationalities, Chengdu 610041, China |
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| Abstract: | Five constituents were extracted from the aerial part of Paederia pertomentosa and isolated by column chromatography. Their structures were elucidated by physicochemical properties and spectroscopic data analysis. The isolated compounds were identified as 1,2-dimethoxy-3,4-dihydroxyanthraquinone named as paederone (1), paederoside (2), deacetyl asperulosidic acid methyl ester (3), paederosidic acid (4) and methylpaederosidate (5). Compound 1 is a new compound which exhibits a significant inhibitory effect on Escherichia coli and Staphylococcus aureus. Compounds 2-5 were isolated from this plant for the first time. |
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| Keywords: | Rubiaceae Paederia pertomentosa chemical constituents iridoid glycoside paederone antimicrobial activity |
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