| 中药三七对大鼠心肌缺血保护作用的谱效学研究 |
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| 引用本文： | 刘旭,李明春,徐霞,纪松岗,徐江平,李秀忠.中药三七对大鼠心肌缺血保护作用的谱效学研究[J].中国现代应用药学,2013,30(8):819-823. |
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| 作者姓名： | 刘旭 李明春 徐霞 纪松岗 徐江平 李秀忠 |
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| 作者单位： | 解放军401医院药剂科，山东 青岛 266071;解放军401医院药剂科，山东 青岛 266071;解放军401医院药剂科，山东 青岛 266071;解放军401医院药剂科，山东 青岛 266071;南方医科大学药理学教研室，广州 510515;解放军401医院药剂科，山东 青岛 266071 |
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| 基金项目： | 国家自然科学基金面上项目(30472178) |
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| 摘 要： | 目的 以大鼠心肌缺血模型为对象，研究中药三七对大鼠心肌缺血保护作用谱效关系及药效物质基础。方法 在建立中药三七液相指纹图谱分析方法的基础上，研究药物治疗心肌缺血作用的物质基础及谱效关系。结果 人参皂苷Rg1、人参皂苷Rb1、三七皂苷R1是中药三七治疗心肌缺血的主要有效成分。结论 通过谱效关系研究直接获得药效活性物质，建立了三七药材谱效关系评价的新方法，客观反映了药物的内在质量，为该类中药的进一步研究提供了新的思路。
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| 关 键 词： | 三七 指纹图谱 谱效关系 |
| 收稿时间： | 2013/3/12 0:00:00 |
| 修稿时间： | 2013/6/29 0:00:00 |
Study on Associativity between Fingerprint of Panax Notoginseng and Curative Effect on Myocardial Ischemia in Rat |
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| LIU Xu,LI Mingchun,XU Xi,JI Songgang,XU Jiangping and LI Xiuzhong.Study on Associativity between Fingerprint of Panax Notoginseng and Curative Effect on Myocardial Ischemia in Rat[J].The Chinese Journal of Modern Applied Pharmacy,2013,30(8):819-823. |
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| Authors: | LIU Xu LI Mingchun XU Xi JI Songgang XU Jiangping and LI Xiuzhong |
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| Institution: | Department of Pharmacy, No.401 Hospital of PLA, Qingdao 266071, China;Department of Pharmacy, No.401 Hospital of PLA, Qingdao 266071, China;Department of Pharmacy, No.401 Hospital of PLA, Qingdao 266071, China;Department of Pharmacy, No.401 Hospital of PLA, Qingdao 266071, China;Department of Pharmacology, Southern Medical University, Guangzhou 510515, China;Department of Pharmacy, No.401 Hospital of PLA, Qingdao 266071, China |
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| Abstract: | OBJECTIVE To study and reveal the spectrum activity relationship and efficacy material foundation of Panax notoginseng on protection of rat myocardial ischemia. METHODS Established Panax notoginseng HPLC fingerprint analytical method and then used the method to research the spectrum activity relationship and efficacy material foundation of Panax notoginseng. RESULTS The main effective components were ginseng saponin Rg1, Rb1 and notoginseng saponins R1. CONCLUSION Through the research on the relationship between the spectrum and efficiency, we directly obtained efficacy active substance and established the new method to evaluate Panax notoginseng medicine spectrum activity relationship. It objectively reflectes the inherent quality of the drugs and provides a new strategy for the further research of traditional Chinese medicine. |
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| Keywords: | Panax notoginseng fingerprint spectrum activity relationship |
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