| Abstract: | Dimethyll-curine dimethochloride was obtainedby methylating the l-curine which was isolated fromplants belonging to Genesia Cyclea widely distributedin Hainan Island, South China. It is a non-depolariz-ing post neuromuscular junctional blocker actingupon N2 receptor. Its chemical structural formula,physical properties, pharmacological actions and acuteor chronic toxicities have been thoroughly studied. Itsbiological activities varied a great deal in differentexperimental animals but their clinical potency isuniform. Its activity is 51.8% as those of d-tubocurarine. Clinically, 1,449 cases, male and female, agedand young, were studied. Among them 422 wereemployed for endotracheal intubation, 468 for muscuIar relaxation and 559 for both. Operation varied,including intracraneal, intra-abdominal and openheart surgery. Different kinds of anesthetics andadjuvants were used in association. I.V. dosage of0.4-0.5 mg/kg or more was enough for intubationwhile 0.2-0.3 mg/kg for relaxation. Average durationof action was 30-40 minutes, but could be prolongedafter heavy doses. Side effects were limited onlyto mild hypotension and temporal face freshness,while cardiovascular disturbances were very insig-nificant. |
