Lack of correlation between impaired Interferon production and natural killer activity of lymphocytes in multiple sclerosis |
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| Authors: | I. Stöger M. Tálas M. Benczúr E. Gyódi G. Gy. Petrányi Gy. Pálffy B. Kotsy |
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| Affiliation: | (1) Microbiological Research Group of the National Institute of Hygiene, Budapest, Hungary;(2) National Institute of Haematology and Blood Transfusion, Budapest, Hungary;(3) Department of Neurology and Psychiatry, Medical School, Pécs, Hungary |
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| Abstract: | Summary The ability of lymphocytes from patients with multiple sclerosis (MS) to produce Interferon (IFN- ) in response to Newcastle Disease Virus (NDV) was studiedin vitro. The correlation between individual IFN- titers and natural killer (NK) cell activity and the presence of HLA system antigens associated with MS (B-7 and DRW-2) was also investigated.Lymphocytes from MS patients showed a significantly impaired capacity to synthesize IFN-in vitro when compared to lymphocytes from healthy donors (mean titers: 85.9 I.U. and 268.2 I.U., respectively). Marked differences in IFN- titers were observed in the group of MS patients.The production of IFN- by the patients' lymphocytes did not correlate with either the activity of NK cells or with their stimulation by exogenous IFN-. There was also no correlation between IFN- production by lymphocytes from MS patients and the presence or absence of B-7 and DRW-2 antigens.With 3 Figures |
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