Blood-brain barrier interfaces and brain tumors |
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Authors: | Sae-Won Lee Woo Jean Kim Jeong Ae Park Yoon Kyung Choi Yoo-Wook Kwon Kyu-Won Kim |
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Affiliation: | Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea. |
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Abstract: | In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenance is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors. |
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Keywords: | Blood-brain barrier Brain angiogenesis Barriergenesis Tight junctions Oxygen tension Glioblastoma |
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