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MAOA-uVNTR Polymorphism May Modify the Protective Effect of ALDH2 Gene Against Alcohol Dependence in Antisocial Personality Disorder |
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| Authors: | Sheng-Yu Lee Cheng-Yi Hahn Jia-Fu Lee Shiou-Lan Chen Shih-Heng Chen Tzung Lieh Yeh Po-Hsiu Kuo I Hui Lee Yen Kuang Yang San-Yuan Huang Huei-Chen Ko Ru-Band Lu |
| Affiliation: | From the Institute of Behavioral Medicine (S-YL, S-HC, H-CK, R-BL);Department of Psychiatry (C-YH, S-LC, TLY, IHL, YKY, R-BL);Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University (C-YH, P-HK);Department of Psychiatry, National Cheng Kung University Hospital (S-YL, C-YH, TLY, IHL, YKY, R-BL), Tainan;Armed Forces Pei-Tou Hospital (J-FL);Department of Psychiatry (S-YH), Tri-Service General Hospital, National Defense Medical Center;Taipei, Taiwan, Republic of China. |
| Abstract: | Background: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). The objective of this study is to determine whether the interaction between the MAOA and the ALDH2 genes is associated with subjects with antisocial personality disorder (ASPD) having alcoholism. Methods: A total of 294 Han Chinese men in Taiwan including 132 ASPD with alcoholism (Antisocial ALC) and 162 without alcoholism (Antisocial Non-ALC) were recruited in this study. Alcohol dependence and ASPD were diagnosed according to DSM-IV criteria. Genotypes of ALDH2 and MAOA-uVNTR were determined using PCR-RFLP. Results: A significant difference of ALDH2 polymorphisms ( p = 3.39E-05), but not of MAOA , was found among the 2 study groups. However, only after the stratification of the MAOA-uVNTR (variable number of tandem repeat located upstream) 3-repeat , a significant association between Antisocial Non-ALC and ALDH2*1/*2 or *2/*2 genotypes was shown ( p = 1.46E–05; odds ratio = 3.913); whereas stratification of MAOA-uVNTR 4-repeat revealed no association. Multiple logistic regression analysis further revealed significant interaction of MAOA and ALDH2 gene in antisocial ALC (odds ratio = 2.927; p = 0.032). Conclusion: The possible interaction of MAOA and ALDH2 gene is associated with Antisocial ALC in Han Chinese males in Taiwan. However, the protective effects of the ALDH2*2 allele against alcoholism might disappear in subjects with ASPD and carrying MAOA-uVNTR 4-repeat allele in the Han Chinese male population. |
| Keywords: | Gene Alcoholism ALDH2 MAOA Antisocial Personality Disorder |