DFP Labeling of Platelets During Recovery from Thrombocytopenia |
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Authors: | EBBE, SHIRLEY SAPIENZA, PETER DUFFY, PETER STOHLMAN, FREDERICK, JR. |
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Affiliation: | 1 St. Elizabeth's Hospital and Tufts Medical School, Boston, Mass.
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Abstract: | Rat platelets were labeled with tritiated diisopropylfluorophosphate(3H-DFP) during recovery from acute thrombocytopenia. The results indicated that there was significant labeling of megakaryocytes by 3H-DFPwhich, in the presence of an increased rate of platelet production, resulted inmaintenance of relatively constant values for platelet-bound radioactivity during the period of maximum platelet production and reactive thrombocytosis.Significant random loss of platelets was apparent, and, when a cohort ofyoung platelets was transfused to normal recipients, they were destroyed at anormal rate. |
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