肺炎衣原体感染与支气管哮喘的研究

目的　探讨肺炎衣原体 (CP)与支气管哮喘的相关性。方法　选择哮喘发作期和缓解期各 31例 ,健康对照组 30例 ,采用金标斑点法检测血清 CP抗体 ,金标斑点法测定血清 Ig M、Ig G,聚合酶链反应检测痰中 CP-DNA。结果　哮喘发作期 CP感染率 35 .5 %明显高于哮喘缓解期和对照组 (P<0 .0 5。哮喘发作期和缓解期 CP感染率分别为 35 .5 %、6 .4 % ,高于对照组 (P <0 .0 5 ) ,同时 Ig M在哮喘发作期 (2 7.3% ) ,Ig G在哮喘缓解期 (36 .4 % )。CP- PCR- DNA测定哮喘发作期 ,缓解期 Ig M组分别为 2 2 .6 %、9.7%、对照组 3.3%。结论　 CP感染为哮喘急性加重的一个重要诱因 ,而且是哮喘反复发作的原因之一。

Study on chlamgdia pneumoniae infection and bronchial asthma

Objective To investigate the association between chlamgdia pneumoniae infection and bronchial asthma. Methods The study sample included 31 patients with acute asthma, 31 patients with asthma in stable condition and 30 healthy subject. The patients' serum CP antibodies, IgM and IgG were measured by the JBB method. The patients' DNA in sputum were detected through nested polymerase chain reaction. Results The incidence of CP infection in the "acute group" (35.5%) was significantly higher than that in the "stable group" (6.4%), which in turn, was higher than that in the healthy subjects: p < 0.05. The values of IgM duirng the acute period was 27.3% and of IgG in the stable condition was 36.4%. The respective rates for DNA for the acute, stable and healthy group were 22.6%, 9.7% and 3.3%. Conclusion The CP infection is one of the important reasons that may lead to further worsing situation in asthmatic patients and for the recurrence of asthma.