急性脑梗死患者血清C反应蛋白水平的变化及其临床意义

目的观察急性脑梗死患者血清C反应蛋白的变化规律,探讨C反应蛋白在急性脑梗死发病中的作用及临床意义。方法采用免疫比浊法对46例急性脑梗死患者血清C反应蛋白水平进行动态观察（病程第1、7及14d）,并与40例健康人进行比较。结果急性脑梗死患者血清C反应蛋白从病程第1天即升高,明显高于对照组（P〈0.01）,第7天达到高峰,以后降低;重症患者明显高于轻、中型患者。结论血清C反应蛋白可能在急性脑梗死的发生、发展中起一定的作用,并与病情程度呈正相关。

The fluctuation of serum C-reactive protein level and R's clinical significance in the patients with acute cerelral infarction

Objective To observe the regularity of fluctuation of serum C-reactive protein（CRP） level in patients with acute cerelral infarction（ACI） and to investigate the relationship between the serum CRP level and the development and prognosis of ACI,and its clinical significance. Methods The serm CRP level was determined seriUy （on day 1.7 and 14 after onsets） by immune turbidity method in 46 patients with ACI and 40 normal controls. Results In ACI group, the serum CRP level increased on first day was significantly（P〈0. 01 ） higher than that in the controls, showing a highest serum CRP level in severe patients. It reached the peak on a seventh day and then tended to decrease gradually. Conclusion This study suggests that high serum CRP level may paly a role in the development of ACI, and serum CRP level is positivly correlated with severity extent of ACI.