| RhoA在卵巢癌组织中的表达及意义 |
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| 引用本文： | 林英姿,陈仁,彭江龙,潘婉,陈锦龙,卢伟英.RhoA在卵巢癌组织中的表达及意义[J].医学综述,2008,14(11):1738-1740. |
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| 作者姓名： | 林英姿 陈仁 彭江龙 潘婉 陈锦龙 卢伟英 |
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| 作者单位： | 1. 海南医学院微免教研室,海口,571101
2. 广东省人民医院感染科,广州,510080 |
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| 摘 要： | 目的探讨RhoA在卵巢癌组织中的表达及其临床意义。方法用免疫组织化学S-P法检测63例卵巢癌患者、17例卵巢良性肿瘤患者和9例正常对照者卵巢组织中RhoA蛋白的表达。结果卵巢癌患者中RhoA阳性率为76.2%,其中强阳性11例(17.5%),明显高于正常对照组和卵巢良性肿瘤组(P<0.01);高分化、中分化和低分化卵巢癌患者RhoA阳性率依次为76.9%、77.8%和66.7%,差异无统计学意义(P>0.05);Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期卵巢癌患者RhoA阳性率依次为69.0%、76.5%、83.3%和100.0%,差异有统计学意义(P<0.05)。结论卵巢癌患者RhoA表达水平高于正常人,其可能参与卵巢癌的发生发展,可作为卵巢癌的临床诊断及预后评估提供有价值的参考。
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| 关 键 词： | 卵巢癌 RhoA 免疫组织化学 |
| 文章编号： | 1006-2084(2008)11-1738-03 |
| 修稿时间： | 2007年5月10日 |
Expression of RhoA in Patients with Ovarian Cancer and Its Clinical Significances |
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| LIN Ying-zi,CHEN Ren,PENG Jiang-long,PAN Wan,CHEN Jing-long,LU Wei-ying.Expression of RhoA in Patients with Ovarian Cancer and Its Clinical Significances[J].Medical Recapitulate,2008,14(11):1738-1740. |
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| Authors: | LIN Ying-zi CHEN Ren PENG Jiang-long PAN Wan CHEN Jing-long LU Wei-ying |
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| Institution: | LIN Ying-zi1,CHEN Ren2,PENG Jiang-long,PAN Wan1,CHEN Jing-long1,LU Wei-ying1.(1.Department of Microbiology , Immunology,Hainan Medical College,Haikou 571101,China,2.Department of Infectious Diseases,Guangdong Provincial People\'s Hospital,Guangzhou 510080,China) |
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| Abstract: | Objective To study on the expression of RhoA in ovarian cancer tissue and its clinical significance.Methods By immunohistochemistry(S-P),the expression of RhoA was detected in 63 ovarian cancer patients,17 ovaries benign tumor patients and 9 health volunteers and evaluated for its clinical significance.Results The positive rates of RhoA in ovaries tissue in patients with ovarian cancer is obviously higher than those in control group and benign tumor(P<0.01).The positive rates of RhoA were 76.9%,77.8% and 66... |
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| Keywords: | Ovarian cancer Ras homolog gene family member A Immunohistochemistry |
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