十一酸睾酮胶丸治疗克氏综合征临床疗效观察

目的：评价十一酸睾酮胶丸治疗克氏综合征的临床疗效。方法：回顾性分析17例克氏综合征患者的临床资料。17例患者均以＂外生殖器发育差＂或＂婚后不育＂就诊,年龄16～35岁,睾丸容积1～12 mL,第二性征发育较差;性激素检查血睾酮值降低（79～320 ng/dL）,卵泡刺激素值升高（22.36～81.30 mIU/mL）,黄体生成素值升高（8.52～37.12mIU/mL）;患者均经外周血染色体检查确诊（16例核型为47XXY,1例为46XY/47XXY）。17例患者均予以十一酸睾酮胶丸行激素替代治疗（120～160 mg/d,分2次饭后立即服用,复查血睾酮水平正常后以低剂量维持治疗）,并随访其治疗效果。结果：17例患者均获随访,其第二性征、性欲和勃起功能得到不同程度的改善,未发现与十一酸睾酮胶丸行激素替代治疗有关的不良反应。结论：十一酸睾酮胶丸替代治疗克氏综合征安全、方便、有效,能提高患者生活质量。

Clinical Observation of Testosterone Undecanoate CapsulesTreatment for Klinefelter Syndrome

Objective： To evaluate the clinical efficacy of Testosterone Undecanoate Capsules treatment for Klinefelter syndrome.Methods： Retrospective analysis the clinical data of patients with Klinefelter syndrome.17 patients sought medical advice because of poorly developed external genitalia or infertility.Their ages ranged 16~35 years old,testicular volume 1~12 mL.Their secondary sexual characteristics were poorly developed.Their serum testosterone values ranged 79~320 ng/dL,follicle-stimulating hormone values 22.36~81.30 mIU/mL,luteinizing hormone values 8.52~37.12 mIU/mL.All patients were diagnosed by peripheral blood chromosome examination（16 cases were 47XXY,1 case was 46XY/47XXY）.All patients were treated with Testosterone Undecanoate Capsules（usage： 120 mg~160 mg/day,twice a day,taken immediately after a meal）,and follow-up of its therapeutic effect.Results： 17 patients were followed up.Their secondary sexual characteristics,libido and erectile functions were improved.Testosterone Undecanoate Capsules therapy-related adverse events were not found.Conclusions： Testosterone Undecanoate Capsules replacement treatment for Klinefelter syndrome is safe,convenient and effective,and can improve patient＇s quality of life.